[dev] [OT] a "suckless" plasmid

[Jens Staal]

Dear all,

Just wanted to share a preprint describing the generation of a minimalistic
plasmid which got 56% size reduction from elimination of "useless bloat" DNA
code, while actually gaining additional functionality (more restriction enzyme
cloning sites).

https://www.preprints.org/manuscript/201807.0287/v2

The preprint paper is not really hypothesis-driven science as such and more a
description of the generation of a very useful tool, so I do not think I will
try to make it published "for real".

[Laslo Hunhold]

On Tue, 16 Oct 2018 09:21:49 +0200
Jens Staal <***@gmail.com> wrote:

Dear Jens,

Post by Jens Staal
Just wanted to share a preprint describing the generation of a
minimalistic plasmid which got 56% size reduction from elimination of
"useless bloat" DNA code, while actually gaining additional
functionality (more restriction enzyme cloning sites).
https://www.preprints.org/manuscript/201807.0287/v2
The preprint paper is not really hypothesis-driven science as such
and more a description of the generation of a very useful tool, so I
do not think I will try to make it published "for real".

this looks really interesting! Thanks for sharing this! I like to think
of DNA as a Turing-tape and "optimizing" it (removing old cruft mostly)
is a very adventurous and futuristic approach.

With best regards

Laslo